Prof. (Dr.) T.R. Borbora, then Vice Principal of Gauhati Medical College, Guwahati was allowed to hold the responsibility of Principal-cum-Chief Superintendent, Barpeta Medical College on 8th August, 2005 and was asked to shouder the responsibility of land acquisition.
Prof. (Dr) D. Hazarika joined as the next Principal of the college on 25th June, 2007 and it is in his tenure the construction works started on the sacred day of 19th December, 2008. His tenure was ended on 2nd of November 2010.
Dr. Kabul Chandra Saikia, MS (Orthopaedics), a renowned Orthopaedician and former Head of Orthopaedics Department of Gauhati Medical College, hailed the post of Principal of Fakhruddin Ali Ahmed Medical College & Hospital, Barpeta. He joined as the third Principal-cum-Chief Superintendent of the college and hospital on 3rd November, 2010. He was then appointed as the Principal of Gauhati Medical College, Guwahati and handed over the charge of Principal of FAAMC to Dr. RK Kalita.
Prof. (Dr.) R.K.Kalita, the Superintendent of the Hospital and Head of the Physiology department acted as the Principal-cum-Chief Superintendent from 01-st Nov, 2011 till 31-01-2012.
Prof. (Dr.) Bhabani Prasad Chakravarty, a renowned physician and former Head of Dept. of Medicine of Guwahati Medical Medical College acted as the Principal-cum-Chief Superintendent from 01-02-2012 till 01-02-2016.
Prof. (Dr.) Arabinda Das, a renowned pathologist of the region and professor of pathology joined as the Principal-cum-Chief Superintendent from 12-02-2016 till 31-05-2017.
Dr. Dilip Kr. Dutta, Professor and Head of the Department of Surgery of Fakhruddin Ali Ahmed Medical College, and Vice-Principal took charge as the Principal on 1st June 2017 and continued in the capcaity till 30-th October 2018.
Prof. (Dr.) Shilpi Rani Barman , has joined as, Principal cum Chief Superintendent of Fakhruddin Ali Ahmed Medical College on 31st Oct,2018. A faculty of Dept. of Microbiology, she was formerly Principal-cum-Chief Superintendent of Silchar Medical College, Silchar. She continued as iin the capacity till 27-th June 2019.